英文论文投稿信Cover letter模板

Dear Editor,

We would like to submit the enclosed manuscript entitled \Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons\which we wish to be considered for publication in Nature Neuroscience.

GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours,

Dear Editor,

We would like to submit the enclosed manuscript entitled \protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release\ We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.

Dear Editor of the [please type in journal title or acronym]:

Enclosed is a paper, entitled \Agents for Network Management.\Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.

1. Title and the central theme of the article.

Paper title: \concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])

3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?

The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system

has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers

to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed

network. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].

4. Names, addresses, and email addresses of four expert referees. Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@lancaster.edu

Expertise: published a related paper (\and OSI: Four Strategies for Interconnection\

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.

Assoc Prof. Dr. John Adams

Director of Network Research Center College of Business Australian University 123, Harbor Drive Sydney, Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886 e-mail: jadams@au.edu.au

Expertise: published a related paper (\18(8), pp. 88-98.

Relationship: None. I have never met Dr. Adams. Assoc Prof. Dr. Chia-Ho Chen Chair of MIS Department College of Management Open University 888, Putong Road Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886 e-mail: chchen@ou.edu.tw

Expertise: published a related paper (\in IJ Electronic Business, 1(4), pp. 18-28.

Relationship: Former professor, dissertation chairman. Mr. Frank Young

Partner, ABC Consulting 888, Seashore Highway Won Kok, Kowloon Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886 e-mail: fyoung@abcc.com

Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.

Relationship: I have worked with Mr. Young in several consulting projects in the past three years.

Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.

Sincerely,

Johnny Smith

Dear Editors:

We would like to submit the enclosed manuscript entitled文章题

目”, which we wish to be considered for publication in “杂志”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.

The goal of the study was to解决问题

We deeply appreciate your consideration of our manuscript and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below. Thank you and best regards. Yours sincerely,

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